FP428MULTIFUNCTIONAL NANOCONSTRUCTS FOR PERORAL DELIVERY OF INSULIN

Development of Plasmonics - active Nanoconstructs for Targeting , Tracking , and Delivery in Single Cells by Molly

Development of Plasmonics-active Nanoconstructs for Targeting, Tracking, and Delivery in Single Cells by Molly K. Gregas Department of Biomedical Engineering Duke University Date:_______________________ Approved: ___________________________ Tuan Vo-Dinh, Supervisor ___________________________ Hisham Massoud ___________________________ Victoria L. Seewaldt ___________________________ Leonard Spi...

In vivo evaluation of physiological efficacy of insulin-loaded nanoliposomes prepared for oral delivery

Introduction: Oral delivery is the most favorable route for insulin administration. The aim of this study was to generate new chitosan coated insulin nanoliposomes and then to assess the physiological efficacy of these nanoliposomes after oral administration in diabetic rabbits. Methods: Nanoliposomes with negative surface charge encapsulating insulin were prepared by reverse phase evaporat...

Evaluation of an Ultrasonic Insulin Delivery System in Hyperglycemic Rabbits

Introduction: Sonophoresis has been assessed as a novel approach to create skin permeability and drug delivery using low frequencies of ultrasound waves in the range of 20 kHz to 3 MHz. In this study, a system including seven 40 kHz piezoelectric transducers and an insulin chamber designed by the Medical Physics Research Center has been evaluated on hyperglycemic rabbits. Materials and Methods:...

Peroral peptide delivery and absorption challenges using novel drug delivery systems: current status

Insulin and glucose in neonatal calves after peroral insulin and intravenous glucose administration.

Effects of peroral insulin on plasma concentrations of immunoreactive insulin (IRI) and glucose in newborn calves were studied. Bovine insulin was administered in amounts of 0.5 mg/kg body weight immediately preceding first colostrum. Thereafter, neither an increased IRI response nor a lowering of blood glucose level were observed, indicating that insulin was either not absorbed from the intest...